Synthesis, characterization and anticancer activity of novel schiff base ligand and its metal complexes

Abstract

This work represents the synthesis of a (E)-1-(1-(4-cyanophenyl)ethylidene) thiosemicarbazide ligand and its Mn(II), Co(II) and Cu(II) complexes. 1H NMR, 13C NMR Spectroscopy, IR and mass spectroscopy were some of the physical and spectral characterisation methods used to examine the produced complexes. The azomethine ligand is effective against microbes, but the metal complexes, especially Mn(II) complexes, were shown to be more effective against Staphylococcus aureus (S. aureus) bacterium. When tested against Aspergillus fumigatus (A. fumigatus ), all of the metal compounds that were produced showed more antifungal effectiveness than when tested against Candida albicans (C. albicans). The compounds of Mn(II), Co(II) and Cu(II) has showed moderate to excellent efficacy when tested for anticancer properties against several cancer cell lines.