Vilsmeier Haack reaction of substituted 2-acetamidothiazole derivatives and their antimicrobial activity

Abstract

Vilsmeier Haack (VMH) reaction of 2-acetamidothiazole having carbethoxy group at C-4 affords the unexpected N-formylated product, which is followed by deacetylation. The same reaction with substituents other than carbethoxy group at C-4 position (<i style="">viz</i> CH₃, CH₂COOC₂H₅, coumarinyl, phenyl, <i style="">etc.</i>) gives the expected C-5 formylated products. The structures of all the newly prepared compounds have been established on the basis of their analytical and spectral data. All the synthesized compounds have been screened for their antimicrobial activity against two strains of bacteria and fungi.