Exploring the Antimicrobial Potential: Synthesis, Characterization, and Insilico Study of a Ni(II) Coordination Complex with 5,7-Dibromo-8-Hydroxyquinoline

Abstract

The current study involves the synthesis of the coordination complex of Ni(II) with derivatives of 8-Hydroxyquinoline in DMSO solvent in order to study their microbial properties. The physical properties of complexes such as color, solubility, melting point, molar conductivity were studied. The low value of molar conductivity shows the non-electrolytic nature of the complex. The synthesized complex was characterized quantitatively and qualitatively by using elemental analysis, FTIR spectroscopy, UV-visible spectroscopy, mass spectroscopy and powdered XRD. The spectroscopic data confirm the chelation of metal to Nitrogen and Oxygen atoms of 5,7-dibromo-8-hydroxyquinoline (HDBQ) and suggest square planar geometry of synthesized complexes. Antimicrobial activities of ligand and synthesized complex were performed against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, Escherichia coli, Fusarium oxysporum, Rhizoctonia solani, Macrophomina phaseolina and Macrophomina spp. Significant effects on the tested microbes is recorded. In silico studies further confirms that the complex synthesized and studied in the present work exhibit promising antibacterial activity which will contribute in the development of new antimicrobial drugs.