Marine natural products as novel therapeutic approaches in Psoriasis: A comprehensive review

Abstract

Psoriasis is a chronic immune-mediated inflammatory skin condition that presents with white, patchy silvery scales with redness and inflammation. These clinical presentations arise due to the hyperproliferation of keratinocytes and modulation of cytokine pathways. The aim of the study is to assess available literature for the usage of marine biomolecules for the management of autoimmune inflammatory disorders than can be implemented for psoriasis. Conventional therapies include topical, phototherapy, targeted biologics and systemic agents which are used to control the disease. In addition, these allopathic medicines have a substantial possible risk of side effects and expected toxicity. Consequently, this provokes the demand for the development of new medications, particularly for psoriasis and other related chronic inflammatory conditions. Up to date, terrestrial natural resources have been well exploited in all standpoints of research including autoinflammatory diseases. Thus, exploring natural products from marine origin might be a distinct perspective. In many literatures, it has been proven that marine natural products have various beneficial effects like anti-inflammatory, antioxidant, immunosuppressive, and antimicrobial properties, which makes them promising treatment strategies for psoriasis management. This review deals with the critical understanding of marine sources with bioactive potential for treating psoriasis and other inflammatory illnesses.