Synthesis, characterization, antimicrobial and antioxidant screening of novel oxazepines

Abstract

Oxazepines 4a-e have been synthesized by condensing aromatic aldehydes with sulfamethoxazole in the presence of chloroform and methanol, resulting in the formation of Schiff bases 3a-e. The Schiff bases have been subsequently condensed with maleic anhydride in dry benzene. The synthesis has been validated through FT-IR, 1H NMR, mass spectrometry and elemental analysis. The compounds of interest have been assessed for their antimicrobial properties against Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and Staphylococcus aureus through the Kirby-Bauer disc diffusion technique. Furthermore, the fluorescence method has been employed to screen for antioxidant activity. The pharmacokinetics of the compounds have been evaluated using computational studies conducted through SwissADME. Additionally, molecular docking studies have been performed on thymidylate synthase A, revealing that the compounds exhibit favorable interactions with the target