Synthesis of some substituted azetidinonyl and thiazolidinonyl-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles as prospective antimicrobial agents

Abstract

Several 2-[(3-chloro-2-substituted phenyl)-4-azetidinon-3-yl]-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles and 2-[(2-substituted phenyl)-4-thiazolidinon-3-yl]-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles have been synthesized. The structures of the synthesized compounds are characterized by elemental and spectral analysis. These compounds are also evaluated for their antimicrobial susceptibility test against <i style="">S.aureus, E.coli, K.pneumoniae, P.vulgaris </i>and<i style=""> A.fumigatus, C.albicans, A. albicans ATCC, C. krusei G03</i> respectively. Compounds <b style="">4c</b> and <b style="">5e</b> showed the most potent antibacrerial and antifungal activities. These two compounds are devoid of any toxicity.