Antimicrobial activity of 1-[<i style="">p</i>{3'-(2'-aryl- 4-oxo-1',3'-thiazolyl)} diphenyl]/[3'-(2'-aryl-4-oxo-1',3'-thiazolyl)]-2-phenyl- 4-cyclohexylidene imidazol-5-ones

Abstract

2-Phenyl-4-cyclohexylidene-1,3-oxozol-5-one <b style="">1</b> has been obtained from the condensation of hippuric acid and cyclohexane using acetic anhydride. The compound <b style="">1</b> is then converted to its respective imidazoles <b style="">2</b> and <b style="">3</b> by condensing with benzidene and hydrazine hydrate. Which on heating with different aromatic aldehydes give 1-(<i style="">p</i>-arylidene-amino-diphenyl)/(arylidene-amino)-2-phenyl-4-cycohexlyidene imidazol-5-one <b style="">4 </b>and <b style="">5</b>. Interaction of <b style="">4 </b>and <b style="">5</b> with thioglycollic acid undergo cyclization to give titled compounds <b style="">6</b> and <b style="">7</b>. The new compounds have been screened for their antimicrobial activity.