Supramolecular assembly with hydrogen bonded network solid formed by reaction of cyanuric chloride with thiourea: Spectral and anitmicrobial studies

Abstract

Interaction of thiourea (Tu) with cyanuric chloride (CC) in aqueous solution yields a compound, (Tu)2(CA)2(NCS)(H2O)3, (CA-TU) (CA = cyanuric acid). The elemental composition, TG-DTA and mass spectrum has confirmed the proposed composition. Infrared bands at 2026 cm–1 and 1725 cm–1 indicates –NCS and >C=O groups respectively along with the –OH and –NH stretching bands. 1H NMR indicates protonated H2O (δ 13.35) and N-H (δ 6.05 - 7.01). The 13C NMR reveals –NCS carbon resonances at δ 116.99 and at δ 178.83 due to thiourea carbon. The signals at δ 150.39, 148.41 and 145.34 are due to CA carbonyls. Thermal studies indicate that step-wise decomposition leading to NH4NO3 takes place and thereafter, to nil residue. The compound is a supramolecular assembly of extensively H-bonded networked solid. The compound has been found to be more effective towards Gram positive bacteria than Gram negative bacteria. The action is superior towards fungi compared to that of the standard Amphotericin-B. The presence of sulphur and nitrogen moieties make it a good antifungal agent