Synthesis, antimicrobial and antimalarial activity of novel carbazole derivatives

Abstract

1-((9H-Carbazol-4-yl)oxy)-3-(piperazine-1-yl) propane-2-ol 3 has been synthesized by condensing epoxy carbazole 1 and piperazine 2. 2-(4-(3-((9H-Carbazol-4-yl)oxy)-2-hydroxypropyl)piperazin-1-yl)-1-phenylpropan-1-one 5a-c derivatives have been synthesized by using 1-((9H-carbazol-4-yl)oxy)-3-(piperazin-1-yl)propan-2-ol 3 and different derivatives of 2-bromo-1-phenylpropan-1-one 4a-c. IR, 1H and 13C NMR, mass spectroscopy and CHN analysis have been used to elucidate the structures of the compounds. The title compounds have been explored for antimalarial and antibacterial activity and have shown promising results.