Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/66990| metadata.dc.identifier.doi: | https://doi.org/10.56042/ijc.v64i12.19411 |
| Title: | Antituberculosis activity of α-aminoacyl amide derivatives |
| Authors: | B Makane, Vitthal U Sinde, Akash Angayarkanni, B Malik, Pradip Chopra, Sidharth |
| Keywords: | Antituberculosis agents;Amides;Tuberculosis;α-Aminoacyl amide |
| Issue Date: | Jan-2025 |
| Publisher: | NIScPR - CSIR |
| Abstract: | The preparation and evaluation of α-aminoacyl amide derivatives against M. tuberculosis H37Rv is reported. The systematic modifications of hit compounds have been carried out. Compounds 19b and 19c are identified as potent and selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 μM and 2.6 μM, respectively. Compounds 19b and 19c hold a promise for further development to discover new potent antituberculosis leads. |
| Page(s): | 1144-1155 |
| ISSN: | 2583-1321 (Online); 0019-5103 (Print) |
| Appears in Collections: | IJC Vol.64(12) [December 2025] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Indian J Chem, 64, 1144-1155 (Dec,2025).pdf | 3.03 MB | Adobe PDF | View/Open | |
| Indian J Chem, 64, 1144-1155 (Dec,2025) Suppl. Data.pdf | 1.98 MB | Adobe PDF | View/Open |
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