Lewis acid-promoted synthesis of 3-tosylisoindolinone from 3-hydroxyisoindolinone: Access to complex furopyrroloisoindoledione

Abstract

An efficient methodology has been developed for the synthesis of sulfur-functionalized isoindolone scaffold from hydroxyisoindolinone via N-acyliminium ion intermediate using TosMIC and Lewis acid in good to excellent yields. The strategy features mild reaction conditions, broad substrate scope and metal-free reaction method. The protocol has been extended for the synthesis of complex furopyrroloisoindoledione derivatives.