Wound healing activity of methanolic extract of leaves of <i style="">Alternanthera brasiliana </i>Kuntz using <i style="">in vivo</i> and <i style="">in vitro</i> model

Abstract

<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> Wound healing activity of methanolic extract of leaves of <i style="">Alternanthera brasiliana</i> Kuntz<i style=""> </i>was<i style=""> </i>studied by excision and incision wound model (<i style="">in vivo</i>) in Sprague Dawley rats and by Chorioallantoic membrane (CAM) model (<i style="">In vitro</i>) in 9 day old embryonated chicken eggs. In excision wound model, compared to the control group, per cent contraction of wound was significantly higher in <i style="">A. brasiliana</i> (5% w/w ointment) treated group. In incision wound model, tensile strength of the healing tissue after treatment with <i>A. brasiliana</i> was found to be significantly higher compared to the control group indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The extract also promoted angiogenesis as evidenced by CAM model. The results suggested that methanolic extract of <i style="">A. brasiliana</i> possess significant wound healing potential in normal wound. </smarttagtype>