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http://nopr.niscpr.res.in/handle/123456789/6751| Title: | Synthesis, characterization and DNA binding and cleavage properties of copper(II)-tryptophan-tryptophan complex |
| Authors: | Reddy, Pulimamidi R Raju, Nomula Reddy, Karnati V |
| Keywords: | Coordination chemistry;Copper;Amino acids;Metallopeptides;Thermal denaturation;DNA quenching;DNA cleavage |
| Issue Date: | Dec-2009 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.9 C07C229/76; C07F1/08 |
| Abstract: | Reaction of copper(II) with tryptophan-tryptophan yields a 1:2 chloro bis(trp-trp) cuprate(II) complex. The complex exhibits absorption band at 620 nm (ε = 130 M -1 cm-1), which suggests a square pyramidal geometry at Cu(II) as observed for other Cu(II)-peptide complexes. The giso value of 2.09 for the complex agrees with a Cu(II) environment of distorted square pyramidal geometry. The mononuclear complex binds to calf thymus DNA through moderate intercalative and weak covalent interactions. It converts the supercoiled plasmid pUC19 DNA to the nicked circular form under physiological conditions. |
| Page(s): | 1638-1643 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.48A(12) [December 2009] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 48A(12) 1638-1643.pdf | 208.32 kB | Adobe PDF | View/Open |
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