Fabricated Fe3O4 as an efficient catalyst for the synthesis of naphthapyranopyrimidines and 5-aryl-1, 2, 4-triazolidine-3-thione under microwave irradiation

Abstract

This study describes the use of iron oxide decorated with SiO2@SO3H as an efficient heterogeneous catalyst for bioactive heterocycles synthesis. The present work describes eco-friendly preparation of magnetic nanoparticles Fe3O4 (MNPs), further functionalized to Fe3O4@SiO2-SO3H. The prepared MNPs and their functionalized materials are fully characterized by FT-IR, XRD, FE-SEM, EDX, HR-TEM, and VSM (published).The modified iron oxide provide faster rate of the reaction for the synthesis of naphthopyranopyrimidine and 5-aryl-1, 2, 4-triazolidine-3-thione (4a, 4c & 4d, and 6d, 6e, 6g, & 6h) in the presence of EtOH and microwave irradiation with excellent product isolation. The synthesized derivative has been recrystallized using ethanol, and homogeneity of the product has been examined by various spectroscopic techniques. Further, the selected derivatives (4a, 4e, 4f, 4g & 4k, and 6a, 6b & 6c) were tested for their antioxidant activities and showed comparable scavenging ability.