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http://nopr.niscpr.res.in/handle/123456789/6868| Title: | Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones |
| Authors: | Prasad, Ashok K Arya, Pragya Bhatia, Sumati Sharma, Raman K Singh, Rishipal Singh, Brajendra K Eycken, Erik Van der Singh, Rajpal Olsen, Carl E Parmar, Virinder S |
| Keywords: | Dihydropyrimidinones;Biginelli condensation;CAL-L(A);enantioselective acylation |
| Issue Date: | Dec-2009 |
| Publisher: | CSIR |
| Abstract: | A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel). The systematic one-step procedure is developed for the synthesis of optically enriched ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 8a-d and acylated ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 9a-e, 10a-e, 11b-d and 12a-e, by the enantioselective acylation of racemic ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates using CAL-L(A). |
| Page(s): | 1738-1748 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.48B(12) December 2009] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 48B(12) 1738-1748.pdf | 251.62 kB | Adobe PDF | View/Open |
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