Hypolipidaemic and antioxidant effects of fruits of <i>Musa </i>AAA (<i style="">Chenkadali</i>) in alloxan induced diabetic rats

Abstract

Hypolipidaemic and antioxidant effects of ethanol extract of mature green fruits of <i style="">Musa</i> AAA (<i>Chenkadali</i>) was evaluated in alloxan induced diabetic rats. The effect of extract at two doses, 500 mg/kg body weight and 1000 mg/kg body weight was analysed and compared with a standard drug, glibenclamide. Rats administered with alloxan showed significantly increased levels of serum triacylglycerol, total cholesterol and alanine amino transferase (ALT) activity. Lipid peroxides increased significantly while reduced glutathione (GSH) decreased considerably in liver and pancreas. Oral administration of the ethanol extract of fruits of <i style="">Musa</i> AAA (<i style="">Chenkadali</i>) significantly decreased the levels of serum triacylglycerol, cholesterol and ALT activity. Significant decrease was also observed in the level of lipid peroxides while GSH content increased substantially in liver and pancreas. The effect was dose independent and rats treated with 500 mg/kg body weight showed comparable levels of serum triacylglycerol, cholesterol, ALT activity and liver lipid peroxides to that of normal control and glibenclamide treated groups. Although, there was no significant difference, treatment with 500 mg/kg body weight of the extract showed a higher content of GSH and lower level of lipid peroxides in pancreas compared with glibenclamide. Histopathological examination of pancreas and liver revealed regeneration of islet cells and hepatocytes respectively, which correlate with the biochemical findings. The present study shows that ethanol extract of mature green fruits of <i style="">Musa </i>AAA (<i>Chenkadali</i>) has antioxidant and hypolipidaemic properties and may be used for treating diabetes mellitus.