Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/7400| Title: | Antihyperglycemic activity of compounds isolated from Indian medicinal plants |
| Authors: | Akanksha Srivastava, Arvind K Maurya, Rakesh |
| Keywords: | Antihyperglycemic activity;Normoglycemic rat model;PTPase-1B;STZ |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Some compounds were also screened in db/db mice. Two compounds (PP-1 and PP-2) inhibited significantly the activity of PTPase-1B in an in vitro system. This might be the underlying mechanism of antihyperglycemic activity of these compounds |
| Page(s): | 294-298 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.48(03) [March 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 48(3) 294-298.pdf | 742.21 kB | Adobe PDF | View/Open |
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