Clay-catalyzed high-speed synthesis of thiadiazepine in one-pot

Abstract

Microwave assisted clay-catalyzed solid state integrated chemical process which enables the consumption of toxic inter-mediates and their isolation from environment, reduce reaction time, cost and complex isolation procedures enhances yields are effective for realizing a green chemical process in library synthe-ses of bio-active compounds. This is described here in the synthe-sis of thiadiazepine. Antifungal screening results on Fusarium oxysporum and Penicillium citrinum show that most of the syn-thesized compounds display promising antifungal activity, compa-rable with griseofulvin and dithane M-45 as standards.