Drug carrier systems for anticancer agents: A review

Abstract

Poor aqueous solubility and adverse effects in cancer treatment using cytotoxicity or hormone therapy are frequently encountered during formulation and usage of conventional drugs. This paper reviews application of various solubilizers and carriers (polymers, cyclodextrins, dendrimers and proteins and amino acids) being used for improving therapeutic efficacy of these agents. Preparation of microspheres, microcapsules and nanospheres to improve aqueous solubility, and potential of liposomes and nanoparticles as effective drug delivery tools have been discussed.