Study of inclusion complexes of valsartan with <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin and hydroxypropyl <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin

Abstract

This study presents improvement in solubility and dissolution rate of valsartan (VAL) using <img src='/image/spc_char/beta.gif' border=0>-cyclodextrin (<img src='/image/spc_char/beta.gif' border=0>CD) and hydroxypropyl-<img src='/image/spc_char/beta.gif' border=0>-cyclodextrin (HP-<img src='/image/spc_char/beta.gif' border=0>CD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, ¹HNMR and <i>in-vitro </i>dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher <i>in vitro </i>drug dissolution rates.