Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/778| Title: | Proline ureas: Synthesis and pharmacological evaluation as VLA-4 antagonists |
| Authors: | Sattigeri, Viswajanani J Soni, Ajay Dastidar, Sunanda G Ray, Abhijit Ahmad, Sharif Gupta, Jung B Salman, Mohammad |
| Keywords: | VLA-4 antagonists;Proline urea;Bioisosteres;Peptidomimetic |
| Issue Date: | Dec-2007 |
| Publisher: | CSIR |
| Abstract: | VLA-4 has been identified as a relatively new target for the development of “non-steroidal” alternatives for the treatment of asthma and related respiratory inflammatory diseases. In continuation of search to identify potent VLA-4 antagonists, a series of novel proline urea derivatives have been synthesized. The newly synthesized compounds are evaluated as potential VLA-4 antagonists in vitro and are found to exhibit moderate VLA-4 inhibitory activity. |
| Page(s): | 2004-2020 |
| ISSN: | 0376-4699 |
| Appears in Collections: | IJC-B Vol.46B(12) December 2007] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 46B(12) (2007) 2004-2020.pdf | 223 kB | Adobe PDF | View/Open |
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