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http://nopr.niscpr.res.in/handle/123456789/8943| Title: | Synthesis, characterization and antimicrobial activities of some fluorine containing 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chlorochromones, 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)chromones and 5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydropyrazolines |
| Authors: | Joshi, N S Shaikh, A A Deshpande, A P Karale, B K Bhirud, S B Gill, C H |
| Issue Date: | Feb-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 231/00 // A 61 P 31/04, 31/10 |
| Abstract: | Base catalyzed condensation of 1 with 2gives compound 3 [1-(5-fluoro-2-hydroxyphenyl)-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-2-propen-1-one]. On oxidative cyclization with DMSO-CuCl2 3 gives 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chloro-6-fluorochromones 4. On cyclization with DMSO-I2, 3 gives 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)- 6-fluorochromones 5. When 3 is heated with hydrazine in dioxane gives 6 [5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(5-fluoro-2-hydroxyphenyl)-4,5-dihydropyrazolines. The products 3, 4, 5 and 6 are characterized by spectral and elemental analysis. Compounds 3, 4 and 6 are tested for their antimicrobial activities. |
| Page(s): | 422-425 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(02) [February 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(2) 422-425.pdf | 99.6 kB | Adobe PDF | View/Open |
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