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http://nopr.niscpr.res.in/handle/123456789/9121| Title: | Bismuth oxide perchlorate catalysed efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones: An improved high yielding protocol for the Biginelli reaction |
| Authors: | Reddy, Y Thirupathi Reddy, P Narsimha Kumar, B Sunil Rao, G V P Rajitha, B |
| Issue Date: | Jun-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 239/00 |
| Abstract: | Dihydropyrimidines are prepared by a one-pot cyclocondensation of aldehydes, β-ketoesters and urea in acetonitrile by using bismuth oxide perchlorate as the catalyst for the first time is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (85-95%) and short reaction time (2-4 hr) at lower temperature (40-50oC). |
| Page(s): | 1304-1306 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(06) [June 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(6) 1304-1306.pdf | 94.55 kB | Adobe PDF | View/Open |
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