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http://nopr.niscpr.res.in/handle/123456789/9139| Title: | Synthesis of novel angularly fused pentacyclic heterocycles of pharmacological interest |
| Authors: | Padmashali, Basavaraj Vaidya, V P Mahadevan, K M Latha, K P |
| Keywords: | Pentacyclic heterocycles;pyrimidines;phosphorus oxychloride;neucleophilic substitution reaction;hydrazine hydrate;furan derivatives;antimicrobial activity;anthelmintic activity;anticonvulsant activity;antipyretic activity |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 31/04, 3110, 25/08, 33/10, 29/00 |
| Abstract: | 2-Substituted-4-oxo-naphtho[2,1-b]furo[3,2-d]pyrimidines 1a-c on refluxing with phosphorous oxychloride result in the formation of 2-substituted-4-chloronaphtho[2,1-b]furo[3,2-d]pyrimidines 2a-c, which on nucleophilic substitution reaction with hydrazine hydrate in ethanol give the required 2-substituted-4-hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 3a-c. The compounds 3a-c are converted into novel angularly fused pentacyclic heterocycles viz. tetrazolo[1,5-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 4a-c and triazolo[4,3-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 5a-i by reacting with appropriate reagents. Condensation of 3a-c with typical aldehydes afford a series of 4-arylidinehydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 6a-o. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data and have been evaluated for antimicrobial, anthelmintic, anticonvulsant and antipyretic activities. |
| Page(s): | 1446-1451 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(07) [July 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(7) 1446-1451.pdf | 56.63 kB | Adobe PDF | View/Open |
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