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http://nopr.niscpr.res.in/handle/123456789/9177| Title: | Synthesis and characterisation of isoquinolinyl quinazolines and a study of their antiviral and antifungal activities |
| Authors: | Pandey, V K Pathak, L P Mishra, S K |
| Keywords: | Isoquinolinyl quinazolines;Antiviral activity;antifungal activity |
| Issue Date: | Sep-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 215/00 //A 61 P 31/10, 31/12 |
| Abstract: | Anthranilic acid on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines 1 which reacts with p-aminobenzoic acid to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines 2. Interaction of 2 with benzoin in the presence of polyphosphoric acid results 2-aryl-3-(3',-4'-diphenylisocoumarinyl)-4-oxo-3H-quinazolines 3, which on reaction with 2-amino-5-aralkyl-1,3,4-thiadiazoles yield 2-aryl-3-[5'-aralkyl-1',3',4'-thiadiazolyl-{2'-(3'',4''-diphenyl-1"-oxo-isoquinolinyl)}]-4-oxo-3H-quinazolines 4. The antifungal and antiviral activities of 4 have been reported. |
| Page(s): | 1940-1943 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(09) [September 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(9) 1940-1943.pdf | 52.05 kB | Adobe PDF | View/Open |
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