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http://nopr.niscpr.res.in/handle/123456789/9220| Title: | Stereoselective synthesis of the enantiomer of the fatty acid component of the potent immunosuppressant, stevastelin |
| Authors: | Raghavan, Sadagopan Reddy, S Ramakrishna Rajitha, B |
| Keywords: | Stereoselective synthesis;enantiomer;fatty acid;immunosuppressant;stevastelin;dimethylcuprate;epoxy alcohol;Grignard reaction |
| Issue Date: | Nov-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C, C 07 D // A 61 P 37/06 |
| Abstract: | A stereoselective synthesis of the enantiomer of the fatty acid chain of stevastelin is disclosed. The C4 methyl group is introduced regio- and stereoselectively via dimethylcuprate opening of epoxy alcohol while the C5 stereogenic center was introduced in a highly stereoselective fashion by Grignard reaction. |
| Page(s): | 2314-2321 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(11) [November 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(11) 2314-2321.pdf | 87.54 kB | Adobe PDF | View/Open |
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