Evaluation of antiinflammatory activity of a Unani formulation

Abstract

The study presents the acute antiinflammatory effect of a non-pharmacopoeal Unani formulation. Both the aqueous and alcoholic extracts were tested for acute antiinflammatory activity by carrageenin oedema test. Since, most of the mainstream antiinflammatory drugs have significant gastric toxicity; therefore test combination was subjected to the test for ulcerogenic activity. The standard drug Piroxicam was used for comparison of antiinflammatory and ulcerogenic activity. The LD50 was also performed to point out the safety margin of test drug. The test drug was found to possess significant antiinflammatory activity against acute inflammation. The test drug also exhibited gastro-friendly effect and the safety margin was very large. The alcoholic extract was more effective than that of aqueous extract.