Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/9979| Title: | In-vitro dissolution rate enhancement of poorly water soluble non-steroidal antiandrogen agent, bicalutamide, with hydrophilic carriers |
| Authors: | Srikanth, M V Babu, G V Murali Mohan Sunil, S A Rao, N Sreenivasa Murthy, K V Ramana |
| Keywords: | Bicalutamide;Dissolution rate;Poloxamer 407;Povidone K 30;Solid dispersion |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | This study presents dissolution rate enhancement of poorly water soluble antiandrogen agent, bicalutamide, using different solubilizing enhancers (Povidone K 30 and Poloxamer 407). Poloxamer 407 based dispersions exhibited higher dissolution ratethan Povidone K 30. Powder X-ray diffraction (PXRD) showed that degree of crystallinity decreased by increasing concentration of Povidone K 30 carrier. FTIR studies showed that drug used was compatible with carriers. Solid dispersion sprepared with povidone K30 changed crystalline form of drug to amorphous form. |
| Page(s): | 629-634 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.69(08) [August 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Jsir 69(8) 629-634.pdf | 199.85 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.