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http://nopr.niscpr.res.in/handle/123456789/10302| Title: | Investigation on crosslinking density for development of novel interpenetrating polymer network (IPN) based formulation |
| Authors: | Banerjee, Subham Chaurasia, Gaurav Pal, Dilipkumar Ghosh, Ashoke Kumar Ghosh, Animesh Kaity, Santanu |
| Keywords: | Controlled release;Crosslinking agent;Interpenetrating polymer network;Microspheres |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Interpenetrating polymer
network (IPN) based formulation, consisting of sodium alginate and poly vinyl
alcohol,
were prepared by water-in-oil
emulsion crosslinking method. IPN based formulation was cross-linked with
glutaraldehyde, and
loaded with diclofenac sodium
(DS) as a model drug. Scanning electron microscopy revealed spherical nature of
microspheres
(size, 472-157  m). Drug entrapment efficiency
(72%) was obtained depending upon concentration of crosslinking density.
Novel formulation can be a potential carrier for controlled delivery of
short half-lived drugs. |
| Page(s): | 777-784 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.69(10) [October 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 69(10) 777-784.pdf | 332.37 kB | Adobe PDF | View/Open |
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