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http://nopr.niscpr.res.in/handle/123456789/15197| Title: | An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug |
| Authors: | Sekharayya, M Chandra Narayana, G Venkata Nigam, Satish Madhusudhan, G |
| Keywords: | Etodolac;7-Ethyltryptophol;2-Ethylphenyl¬hydrazine hydrochloride;Anti-inflammatory drug N,N-dimethylacetamide |
| Issue Date: | Dec-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An improved and scalable method is developed for the synthesis of 7-ethyltryptophol, a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug (NSAID) starting from commercially available 2-ethylphenyl hydrazine and dihydrofuran with H2SO4 as a catalyst in N,N-dimethylacetamide (DMAc)-H2O (1:1) as a solvent in 69% yield. The method is easy, inexpensive and reproducible and the process is clean, high yielding and operationally simple. |
| Page(s): | 1763-1766 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.51B(12) December 2012] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 51B(12) 1763-1766.pdf | 64.7 kB | Adobe PDF | View/Open |
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