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http://nopr.niscpr.res.in/handle/123456789/15291| Title: | Influence of 7β-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: In vitro studies |
| Authors: | Bansal, Geetanjali Singh, Uma Bansal, M P |
| Issue Date: | Jun-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Incubation of murine peritoneal macrophages with 7β hydroxycholesterol (7 β -OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7 β -OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system |
| Page(s): | 176-179 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.38(3) [June 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 38(3) 176-179.pdf | 1.05 MB | Adobe PDF | View/Open |
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