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http://nopr.niscpr.res.in/handle/123456789/15431| Title: | Induction of apoptosis in AK-5 cells by rotenone involves participation of Caspases |
| Authors: | Khar, Ashok Ali, A Mubarak Begum, Zareena Pardhasaradhi, B V V Varalakshmi, Ch |
| Issue Date: | Apr-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | AK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis.DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells. |
| Page(s): | 77-81 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.36(2) [April 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 36(2) 77-81.pdf | 1.16 MB | Adobe PDF | View/Open |
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