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http://nopr.niscpr.res.in/handle/123456789/16127| Title: | Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm |
| Authors: | Ghanbari, Ali Khazaei, Mozafar Hashemi-Tabar, Mahmoud Rabzia, Arezou Fathi, Fardin Bayat, Parvin-Dokht |
| Keywords: | Definitive endoderm;Dithizone;Hedgehog interacting protein;Mesendoderm;Mouse embryonic stem cell |
| Issue Date: | Mar-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages. |
| Page(s): | 201-207 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.51(03) [March 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 51(3) 201-207.pdf | 333.54 kB | Adobe PDF | View/Open |
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