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http://nopr.niscpr.res.in/handle/123456789/16185| Title: | Synthesis and biological activities of new 3,5-disubstituted -2-( ethyl-5'-thioxo-1',3',4'-oxadiazol-4'-ethylacetate-2'-yl)indoles,-2-(5'- thioxo-1',3',4'-oxadiazol-4'methylcarboxyhydrazide-2'-yl) indoles and -2-(5'- thioxo-1',3', 4'-oxadiazol-4'alkyl- 2'-yl) indoles |
| Authors: | Patil, Renukadevi Biradar, J S |
| Issue Date: | Jan-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3,5-Disubstituted indole-2-carboxylates 1 a-g are reacted with hydrazine hydrate to furnish the corresponding indole-2-carboxyhydrazides 2a-g These on reaction with alkaline carbon disulphide under thermal reaction conditions produce respective 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl) indoles 3a-g. Reaction of 3a-g with ethyl chloroacetate and alkyl halides in dry acetone and anhyd, K2CO3 yield indoles 4a-g and 6a-r, respectively. Compounds 4a-g on further reaction with hydrazine hydrate in ethanol afforded the compounds 5a-g. Compounds synthesised have been screened for their biological activities. |
| Page(s): | 76-82 |
| Appears in Collections: | IJC-B Vol.38B(01) [January 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(1) 76-82.pdf | 1.28 MB | Adobe PDF | View/Open |
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