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http://nopr.niscpr.res.in/handle/123456789/16475| Title: | Synthesis and reactions of some new 5-aryl-3-oxo-7 -(4'-aryl-2' ,5 '-dioxo-1', 2' ,3 ', 4'-tetrahydrofluoren-3'-yl)-5H, 8H-2,3- dihydrothiazolo[5,4-b]pyrimidines of expected biological activity |
| Authors: | Salama, M A EI-Essa, S A |
| Issue Date: | Jun-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Arylidene-indane-1,3-dione 1 on treatment with acetyl acetone in gl. acetic acid gives 3-acetyl-4-aryl-2,5-dioxo-1,2,3,4- tetrahydrofluorenes 2a-d which on reaction with benzaldehyde yield 4-aryl-3-cinnamoyl-2, 5-dioxo-1, 2, 3, 4-tetrahydrofluorenes 3a-d. Compounds 3a-d when reacted with thiourea in gl. CH3COOH/Ac2O in the presence of anhyd. sodium acetate afford 4,5-diaryl-6-(4'-aryl-2', 5' -dioxo-1', 2', 3', 4'-tetrahydrofluoren- 3'-yl)-1, 2, 3, 4-tetrahydropyrimidine-2-thiones 4a-d which on treatment with chloroacetic acid furnish 5-aryl-3-oxo-7-(4'-aryl- 2', 5' -dioxo-1',2',3',4' -tetrahydrofluoren-3'-yl)-5H, 8H-2,3-dihydrothi azolo[5,4-b]pyrimidines 5a-d. Compounds 5a-d on condensation with benzaldehyde yield 2-arylmethylene-3-oxo-Sphenyl-7-(4' -aryl-2', 5' -dioxo-1', 2', 3', 4'-tetrahydrotluoren-3'yl)-5H, 8H-2,3-dihydrothiazolo[5,4- b ]pyrimidines 6a-d. |
| Page(s): | 739-742 |
| Appears in Collections: | IJC-B Vol.38B(06) [June 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(6) 739-742.pdf | 641.8 kB | Adobe PDF | View/Open |
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