Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/16502| Title: | Synthetic modifications of ascomycin : Part III1 - A concise transformation of iso-ascomycin to 19, 20-seco-derivatives |
| Authors: | Zimmer, Reinhold Grassberger, Maximilian A Baumann, Karl Zenke, Gerhard Schuler, Walter |
| Issue Date: | Jul-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A short transformation of 22(R)-dihydro-iso-ascomycin to novel 19, 20-seco-iso-ascomycin derivatives is described. The biological activity of the new compounds is compared with that of standards in assays relevant for ascomycin/FK 506 type compounds (macrophilin-12 binding assay, IL-2 reporter gene assay). The results indicate that the 19, 20-seco-derivative 3 might develop into a key intermediate for the synthesis of new derivatives with interesting biological activities. |
| Page(s): | 831-834 |
| Appears in Collections: | IJC-B Vol.38B(07) [July 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(7) 831-834.pdf | 723.68 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.