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http://nopr.niscpr.res.in/handle/123456789/16503| Title: | Some reactions of 2-phenyl-4(3H)-quinazolinones |
| Authors: | Abdo, Mohamed A Zeid, Ibrahim F EI-Hiti, Gamal A Mahmoud, Olfat E |
| Issue Date: | Jul-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Reaction of 2-phenyl-3, 1-benzoxazin-4H-one 1 with thiocarbohydrazide in refluxing ethanol affords 2-phenyl-3- thiosemicarbazido-4(3H)-quinazolinone 2. However, thioxotetrazinoquinazo line 3 is obtained in 79% isolated yield when the reaction mixture is fused in an oil bath at 160°C. Compound 3 is also obtained when compound 2 is heated in an oil bath at 170°C. On the other hand , compound 3 reacts with paraformaldehyde and secondary amines to afford the corresponding quinazoline derivatives 4 and 5. The diazonium salt of 3-amino-2-phenyl- 4(3H)-quinazolinone 6 reacts with some active methylene compounds (diethyl malonate, ethyl acetoacetate, malononitrile and acetyl acetone) to affords the quinazolinone derivatives 8-11 in good yields. Reactions of 8 with hydrazine hydrate and phenyl hydrazine afford the corresponding pyrazolonoquinazolinones 12 and 13, respectively. Reaction of 8 with urea furnishes pyrimidinoquinazolinones 14 in 79% isolated yield. However, reaction of 11 with hydrazine hydrate gives pyrazoloquinazolinones 15 in 83% isolated yield. |
| Page(s): | 850-853 |
| Appears in Collections: | IJC-B Vol.38B(07) [July 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(7) 850-853.pdf | 755.46 kB | Adobe PDF | View/Open |
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