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http://nopr.niscpr.res.in/handle/123456789/16600| Title: | Synthesis and antimicrobial activity of some new 2-aminomethyl -5-(4-phenyl-5- mercapto-1,2,4-triazol-3-yl)methoxyindole derivatives |
| Authors: | Gadaginamath, G S Patil, SA |
| Issue Date: | Sep-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 6-Bromo-2-bromometh yl-1-butyl-3-ethoxycarbonyl-5- ethoxycarbonylmethoxyindole 2 has been prepared from 2-methylindole derivative 1 using NBS as regioselective brominating agent in the presence of radical initiator like dihenzoyl peroxide. Compound 2 is then reacted with amines to yield corresponding 2-aminomethylindole diesters 3a-b. Hydrolysis of 3a-b by ethanolic sodium hydroxide gives the corresponding diacids 4a-b. Diesters 3a-b also react chemoselectively with excess of hydrazine hydrate (99 %) to yield the corresponding monocarbohydrazides 5a-b instead of the expected dicarbohydrazides 6a-b. The monocarbohydrazides 5a-b on reaction with phenylisothiocyanate followed by treatment with NaOH (4 %) solution afford the required 2-aminomethyl-5-(4-phenyl-5-mcrcapto- 1,2,4-triazol- 3-yl )methoxyindole derivatives 5a-b. All the newly synthesised compounds are screened for their antimicrobial activities. |
| Page(s): | 1070-1074 |
| Appears in Collections: | IJC-B Vol.38B(09) [September 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(9) 1070-1074.pdf | 1.07 MB | Adobe PDF | View/Open |
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