Synthesis and antibacterial activity of some novel spiro [3<i>H</i>-indole-3,5'-[1 ,3,4]oxadiazolo[3,2-c]thiazole]-2(1<i>H</i>)-ones and [1,3,4]oxadiazino[6,5-b]indoles  containing 1 ,8-naphthyridine moiety

Mogilaiah, K; Reddy, P Raghotham; Rao, R Babu

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/16630

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DC Field	Value	Language
dc.contributor.author	Mogilaiah, K	-
dc.contributor.author	Reddy, P Raghotham	-
dc.contributor.author	Rao, R Babu	-
dc.date.accessioned	2013-03-29T19:23:27Z	-
dc.date.available	2013-03-29T19:23:27Z	-
dc.date.issued	1999-10	-
dc.identifier.issn	0975-0983(Online); 0376-4699(Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/16630	-
dc.description	1203-1207	en_US
dc.description.abstract	Interaction of 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 1 with different isatins 2 gives the corresponding isatin-β-(2-prenyl-1,8-naphthyridine-3-carbonylhydrazones) 3. Cyclocondensation of 3 with mercaptoacetic acid in DMF in the presence of anhyd. ZnCI₂ affords 3' -(2-phenyl-1,8-naphthyridine-3-carbonylamino )spiro[3 H-inole-3,2'thiazolidine ]-2,4' (1H)-diones 4, which on treatment with conc. H₂S0₄ undergo cyclodehydration to furnish the desired 2' (2-phenyl-1,8-naphthyridin-3-yl) spiro[3H-indole-3,5' -[1,3,4]oxadiazolo[3,2-c ]thiazole]-2(1H)-ones 5. On the other hand, the hydrazones 3 on treatment with conc. H₂S0₄ leads to the formation of 2-(2-phenyl-1,8-naphthyridin-3-yl)[1,3,4]oxadiazino[6,5-b]indoles 6. The structures of the compounds 3-6 have been established on the basis of their elemental analyses and spectral (IR, ¹H NMR and mass) data. The compounds 5 and 6 have been screened for their antibacterial activity.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJC-B Vol.38B(10) [October 1999]	en_US
dc.title	Synthesis and antibacterial activity of some novel spiro [3H-indole-3,5'-[1 ,3,4]oxadiazolo[3,2-c]thiazole]-2(1H)-ones and [1,3,4]oxadiazino[6,5-b]indoles containing 1 ,8-naphthyridine moiety	en_US
dc.type	Article	en_US
Appears in Collections:	IJC-B Vol.38B(10) [October 1999]

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