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http://nopr.niscpr.res.in/handle/123456789/16630| Title: | Synthesis and antibacterial activity of some novel spiro [3H-indole-3,5'-[1 ,3,4]oxadiazolo[3,2-c]thiazole]-2(1H)-ones and [1,3,4]oxadiazino[6,5-b]indoles containing 1 ,8-naphthyridine moiety |
| Authors: | Mogilaiah, K Reddy, P Raghotham Rao, R Babu |
| Issue Date: | Oct-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Interaction of 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 1 with different isatins 2 gives the corresponding isatin-β-(2-prenyl-1,8-naphthyridine-3-carbonylhydrazones) 3. Cyclocondensation of 3 with mercaptoacetic acid in DMF in the presence of anhyd. ZnCI2 affords 3' -(2-phenyl-1,8-naphthyridine-3-carbonylamino )spiro[3 H-inole-3,2'thiazolidine ]-2,4' (1H)-diones 4, which on treatment with conc. H2S04 undergo cyclodehydration to furnish the desired 2' (2-phenyl-1,8-naphthyridin-3-yl) spiro[3H-indole-3,5' -[1,3,4]oxadiazolo[3,2-c ]thiazole]-2(1H)-ones 5. On the other hand, the hydrazones 3 on treatment with conc. H2S04 leads to the formation of 2-(2-phenyl-1,8-naphthyridin-3-yl)[1,3,4]oxadiazino[6,5-b]indoles 6. The structures of the compounds 3-6 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data. The compounds 5 and 6 have been screened for their antibacterial activity. |
| Page(s): | 1203-1207 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.38B(10) [October 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(10) 1203-1207.pdf | 929.73 kB | Adobe PDF | View/Open |
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