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Title: Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
Authors: Agarwal, Ramesh B
Rangari, Vinod D
Keywords: Anti -arthritic activity;Anti-inflammatory activity;Essential oil of Strobilanthus;Strobilanthus ixiocephala
Issue Date: Aug-2003
Publisher: NISCAIR-CSIR, India
Abstract: Column chromatographic fractionation of essential oil obtained by hydrodistillation from the flowering tops of S.ixiocephala resulted in the isolation of β-caryophyllene, fenchyl acetate, T-cadinol and a new sesquiterpene alcohol for which a name ixiocephol has been proposed. The β-caryophyllene and fenchyl acetate were identified by Co-TLC with authentic samples whereas T-cadinol and ixiocephol were structurally elucidated by UV, IR,1H NMR,13C NMR and Mass spectral data. The GC-MS analysis of the essential oil has also revealed the presence of various monoterpenoids and sesquiterpenoids. The essential oil of S. ixiocephala demonstrated a dose dependant anti-inflammatory activity in carrageenan-induced rat paw oedema. It has also revealed good activity in cotton pellet granuloma and adjuvant induced arthritis model in rats.
Page(s): 890-894
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(08) [August 2003]

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