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http://nopr.niscpr.res.in/handle/123456789/18246| Title: | Kinetics of substitution of aqua ligands from cis-diaqua (ethylenediamine)platinum(II) perchlorate by guanosine in aqueous medium |
| Authors: | Sengupta, Partha S Sinha, Ramanath Bera, Sujit K De, Gauri S |
| Issue Date: | Apr-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The kinetics of the interaction of guanosine with cis-[Pt(en)(H2O)2]2+ + have been studied spectrophotometrically as a Function of [Pt(en)(H2O)22+], [guanosine] and temperature at pH 4.0 where the substrate complex exists predominantly as the diaqua species. Base stacking and metal induced macrochelate formation of guanosine plays a vital role in determining the concentration limit of guanosine during kinetics. Substitution occurs in two consecutive steps; both dependent on the guanosine concentration. Activation parameters for both steps have been calculated. The low ∆H1# (36.28 ± 0.5 kJ mol-1) and large negative values of ∆S1#(- 125.3 ± 1.5 J K-1 mol-1) as well as ∆H2# (36.03 ± 0.6 kJ mol-1) and ∆S2# (-149.2 ± 1.9 J K-1 mol-1) indicate associative modes of activation for both the ligand substitution processes ill the two consecutive steps. |
| Page(s): | 712-717 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.41A(04) [April 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 41A(4) 712-717.pdf | 1.38 MB | Adobe PDF | View/Open |
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