Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/19425| Title: | Hypoglycaemic effect of the traditional drink, the water extract of dried flowers of Aegle marmelos (L.) Correa (bael fruit) in Wistar rats |
| Authors: | Kumari, K D K P Samarasinghe, K Suresh, T S |
| Keywords: | Traditional drink;Aegle marmelos;Hypoglycaemic;Diabetes;Rats |
| Issue Date: | Jul-2013 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A61K 36/00, A01D 16/02, A47G 19/26, A47J 39/02, C12G, C12C 12/04, C12G 3/08, C12H 3/00, A23L 2/00, A01D 20/00 |
| Abstract: | This study was designed to prove scientifically the medicinal benefits of a traditional drink. In this study the oral hypoglycaemic effect of the water extract of dried flowers of A. marmelos (L.)Correa (WEAM) was evaluated using Wistar rats. Healthy and alloxan-induced diabetic rats were kept on overnight fasting and they received the WEAM, drugs or distilled water, 30 min prior to glucose loading (3 gm/kg). Blood was collected after 2 hrs and serum glucose concentrations were determined by the glucose oxidase method. This procedure was repeated to determine the optimum dose and time, to evaluate the effect of the multiple doses and to compare the activity with reference drugs, Metformin and Glibenclemide. The extract gave statistically significant (p< 0.05) hypoglycaemic effect in both healthy and diabetic rats. The optimum activity was showed by 500 mg/kg at 2 hrs after the administration of glucose. The effectiveness of the WEAM was comparable with the reference drugs Metformin and Glibenclemide. The administration of the extract for a period of 42 days showed an increased hypoglycaemic (p < 0.01) effect and glycated haemoglobin level was reduced significantly (p < 0.01) in diabetic rats. The water extracts of dried flowers of Aegle marmelos posses a significant oral hypoglycaemic effect. |
| Page(s): | 384-389 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Appears in Collections: | IJTK Vol.12(3) [July 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJTK 12(3) 384-389.pdf | 68.04 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.