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http://nopr.niscpr.res.in/handle/123456789/20020| Title: | Solubility enhancement of rofecoxib in water in the presence of hydrobhilic polymers, surfactants, co-solvents, and small molecules at310.15K† |
| Authors: | Desai, K H Kulkarni, A R Agnihotri, S A Gudasi, K B Aminabhavi, T M |
| Issue Date: | Jul-2006 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8 A61 K |
| Abstract: | Solubility enhancement of rofecoxib in water has been studied in presence of different conce ntrations of hydrophilic polymers like polyethylene glycol-4000 polyethylene glycol-6000 and polyvinylpyrrolidone (PVP- K30); surfactants like Span-20, Tween-80 and sodium lauryl sulfate (SLS): co-solvents like ethanol, propylene glycol and glycerol and small molecules like urea, mannitol and β-cyclodextrin at 310.15 K. Drug analysis has been carried out by HPLC method using UV detector at 254 nm. Drug solubility is greatly enhanced in the presence of PVP-K30, SLS, and ethanol. In the presence of small molecules, urea enhances the solubility much higher than mannitol or β-cyclodextrin. |
| Page(s): | 1667-1669 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.45A(07) [July 2006] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 45A(7) 1667-1669.pdf | 628.6 kB | Adobe PDF | View/Open |
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