Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/21674| Title: | Synthesis, antiinflammatory and antibacterial activity of some new flavonoidal derivatives |
| Authors: | Khan, M S Y Hasan, S M |
| Issue Date: | Aug-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Several new flavones/flavanones and 5'-substituted-2'-hydroxy chalcones have been synthesised through Claisen Schmidt condensation. 5-Chloromethyl-2-hydroxy acetophe none 1 on condensation with various aromatic aldehydes yields chalcones 2a and 2b, which on cyclisation in presence of SeO2 give corresponding flavones 2c and 2d respectively. Compound 3 is obtained from 1 by reacting with o-toluidine. Further condensation of 3 with different aromatic aldehydes gives the corresponding chalcone/flavone derivatives 3a-e. The synthesised flavonoid derivatives are evaluated for their antiinflammatory activity on carrageenan induced paw edema in rats and in vitro antibacterial activity. The results have been encouraging. |
| Page(s): | 1970-1974 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(08) [August 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(8) 1970-1974.pdf | 876.81 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.