Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/22565| Title: | An expedient synthesis of racemic combretastatin and isocombretastatin |
| Authors: | Jain, Niveta Krishnamurty, H G |
| Issue Date: | Nov-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The stilbenoid constituents of Combretum caffrum possess pronounced antineoplastic and antimitotic activities. The most potent agents are R (-) combretastatin 1, and combretastatins A-1 to A-4. A novel and simple method for the synthesis of ±1 and isocombretastatin 5 in which an appropriately substituted 1, 3-diarylpropanoid is transformed into a stilbenoid is described. The key step involves the alkali induced rearrangement of chalcone epoxide 9 to α-hydroxy acid 10 and that is followed by oxidative decarboxylation and reduction. |
| Page(s): | 817-821 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.39B(11) [November 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 39B(11) 817-821.pdf | 956.87 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.