Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23797| Title: | Phostoxin-induced biochemical and pathomorphological changes in rabbits |
| Authors: | Okolie, Ngozi Paulinus Aligbe, Jonathan Umezuluike Osakue, Edorisiagbon Eguagu |
| Keywords: | Phostoxin;Tissue Lesions;Hematology;ATPases |
| Issue Date: | Nov-2004 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8 mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na+-K+ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca2+-ATPase and Mg2+-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney. |
| Page(s): | 1096-1099 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.42(11) [November 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 42(11) 1096-1099.pdf | 1 MB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.