Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23829| Title: | Effect of nimesulide co-administration on pharmacokinetics of lithium |
| Authors: | Sidhu, Shabir Kondal, Amit Malhotra, Samir Garg, S K Pandhi, P |
| Keywords: | Lithium;Nimesulide;Pharmacokinetics;Drug Interaction |
| Issue Date: | Dec-2004 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In a crossover study, lithium was given orally at a dose of 56 mg/kg, prepared as suspension (0.5%) in carboxymethyl cellulose (CMC) and blood samples (l ml) collected after 0-24 hr after drug administration. After a washout period of two weeks, nimesulide (10mg/kg) was administered alongwith lithium (56 mg/kg) and blood samples were drawn at the same time intervals (0-24 hr) after drug administration. Plasma was separated and assayed for lithium by M 654 Na+/K+/Li+ analyzer and various pharmacokinetic parameters were calculated. Cmax, Kel, t1/2el and AUC0-α of lithium were significantly increased when nimesulide was administered along with lithium as compared to control group. |
| Page(s): | 1248-1250 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.42(12) [December 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 42(12) 1248-1250.pdf | 566.11 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.