Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/34280| Title: | Dillenia indica L. exhibited hematoprotective effects via modulation of antioxidant responsive enzymes |
| Authors: | Shukla, Pooja Asthana, RK Srivastava, MN Singh, RK |
| Keywords: | Hematoprotective;Dillenia indica L.;Anti-oxidants;Free-radical;Anti-oxidant intrinsic defence |
| Issue Date: | Jul-2016 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A61K 36/00, C09K 15/00, C07B 61/00 |
| Abstract: | The present studies were intended towards finding a suitable plant based natural product which can ameliorate the hematotoxicity encountered as adverse drug reactions (ADRs) in various therapeutic regimens. Dillenia indica (DI) is used in folklore and traditional medicine as general health enhancer. The aim of the study was to evaluate the hematoprotective effects of natural botanical, Dillenia indica (DI) ethanolic extract (DIEE), employing a Phenylhydrazine (Phz)-induced hematotoxicity model of Sprague Dawley (SD) rats. DIEE exhibited hematoprotective effects In vitro and In vivo. Solvent guided Fractionation studies revealed the presence of high amounts triterpenoids in DIEE. DIEE showed radical scavenging properties in DPPH radical scavenging assay. Mechanism based studies unveiled the positive effects of DIEE on antioxidant enzymes Superoxide dismutases 2 and 3 (SOD’s) and Nuclear erythroid 2 p45-related factor 1 (Nfer- 1) and Nuclear erythroid 2 p45-related factor 2 (Nfer-2) employing quantitative real time PCR. In toxicity studies in SD rats, DIEE imparted no toxicity. The results are of integral significance as, the study establishes the folklore and traditional medicine claims about the peremptory actions of DI. |
| Page(s): | 433-439 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Appears in Collections: | IJTK Vol.15(3) [July 2016] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJTK 15(3) 433-439.pdf | 122.4 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.