Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines

Chandrika, P Mani; Yakaiah, T; Narsaiah, B; Sridhar, V; Venugopal, G; Rao, J Venkateshwara; Kumar, K Pranay; Murthy, U S N; Rao, A Raghu Ram

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Title:	Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines
Authors:	Chandrika, P Mani Yakaiah, T Narsaiah, B Sridhar, V Venugopal, G Rao, J Venkateshwara Kumar, K Pranay Murthy, U S N Rao, A Raghu Ram
Keywords:	Benzoylation;acylation;cyclisation;quinazolones;quinazolines
Issue Date:	Jun-2009
Publisher:	CSIR
Abstract:	A series of novel 2,4,6-trisubstituted quinazoline derivatives 6 have been synthesized from anthranilic acids 1 in five steps via benzoxazinones 2, N-benzoyl benzamides 3, quinazol-4-ones 4, 4-chloroquinazolines 5. Products 6 have been screened for antibacterial and cytotoxic activity, promising compounds have been identified.
Page(s):	840-847
ISSN:	0376-4699
Appears in Collections:	IJC-B Vol.48B(06) [June 2009]

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